EARLY PATTERNING OF THE C. ELEGANS EMBRYO

作者：Lesilee S. Rose, Kenneth J. Kemphues · 发表于：Annual Review of Genetics · 年份：1998 · DOI：10.1146/annurev.genet.32.1.521 · 被引用次数：174 · 研究领域：Genetics, Aging, and Longevity in Model Organisms、Pluripotent Stem Cells Research、Reproductive Biology and Fertility

Studies of about 20 maternally expressed genes are providing an understanding of mechanisms of patterning and cell-fate determination in the early Caenorhabditis elegans embryo. The analyses have revealed that fates of the early blastomeres are specified by a combination of intrinsically asymmetric cell divisions and two types of cell-cell interactions: inductions and polarizing interactions. In this review we summarize the current level of understanding of the molecular mechanisms underlying these processes in the specification of cell fates in the pregastrulation embryo.