Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in water

作者：Xiaoliang Yang, Chun‐Mei Xu, Shao-Miao Lin, Jiu‐Xi Chen, Jinchang Ding, Huayue Wu, Weike Su · 发表于：Journal of the Brazilian Chemical Society · 年份：2010 · DOI：10.1590/s0103-50532010000100007 · 被引用次数：49 · 研究领域：Multicomponent Synthesis of Heterocycles、Synthesis and biological activity、Synthesis and Characterization of Heterocyclic Compounds

A series of 2-substituted benzothiazoles have been synthesized by the condensation of 2-aminothiophenol with aldehydes (RCHO: R = Alkyl, Aryl, Heteroaryl, 2-Arylformyl) in the presence of a catalytic amount of cetyltrimethyl ammonium bromide (CTAB) "on water" by a one-pot procedure without additional organic solvents and oxidants. Thereinto, 2-alkylbenzothiazoles were synthesized in high yields and 2-arylformylbenzothiazoles were obtained from the condensation of 2-aminothiophenol with arylformyl aldehydes for the first time using the present protocol.