Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity

作者：Marianne Broome Powell, Dennis J. Mitchell, Jennifer R Lederman, Julie A. Buckmeier, Scott S. Zamvil, Mark J. Graham, Nancy H. Ruddle, Lawrence Steinman · 发表于：International Immunology · 年份：1990 · DOI：10.1093/intimm/2.6.539 · 被引用次数：288 · 研究领域：Multiple Sclerosis Research Studies、Olfactory and Sensory Function Studies、Neuroinflammation and Neurodegeneration Mechanisms

Lymphokine activity in seven myelin basic protein (MBP)-specific T cell clones was examined. All of the clones recognize MBP peptide 1-9 in the context of I-Au. A strong positive correlation was found between levels of lymphotoxin (LT) and tumor necrosis factor alpha (TNF-alpha) mRNA and biological activity on L929 cells and their capacity to induce paralysis, the clinical hallmark of experimental allergic encephalomyelitis (EAE). No correlation was found between interleukin-2 or gamma interferon production and encephalitogenicity. LT and/or TNF-alpha may play a central role in the pathogenesis of EAE.