The Role of Oxygen in Wound Healing: A Review of the Literature

作者：PAOLA G. RODRIGUEZ, FRANCES N. FELIX, David T. Woodley, ELISABETH K. SHIM · 发表于：Dermatologic Surgery · 年份：2008 · DOI：10.1111/j.1524-4725.2008.34254.x · 被引用次数：374 · 研究领域：Wound Healing and Treatments、Diabetic Foot Ulcer Assessment and Management、Pressure Ulcer Prevention and Management

BACKGROUND: The presence of oxygen is necessary for normal wound healing. Oxygen has been given as a therapeutic modality to assist and speed wound healing. OBJECTIVE: The objective was to summarize the role of oxygen in wound healing. MATERIALS AND METHODS: A literature review of clinical and basic science studies regarding oxygen and wound healing was conducted. RESULTS: Hypoxia appears to jump start wound healing via hypoxia-inducible factor 1alpha and reepithelialization. Nonetheless, oxygen is often required to start or sustain other wound healing processes. CONCLUSION: Both the absence and the presence of oxygen have effects on wound healing; however, its role is not completely understood. Although hyperbaric oxygen and topical oxygen therapy have been described in aiding wound healing, case-controlled prospective studies are lacking and evidence for their efficacy is inconsistent. The authors have indicated no significant interest with commercial supporters.