Malignant schwannoma. A light microscopic and ultrastructural study

作者：Karl T. K. Chen, Rocco Latorraca, Douglas R. Fabich, Andrew Padgug, Gaye Hafez, Enid F. Gilbert · 发表于：Cancer · 年份：1980 · DOI：10.1002/1097-0142(19800401)45:7<1585::aid-cncr2820450712>3.0.co;2-p · 被引用次数：79 · 研究领域：Neurofibromatosis and Schwannoma Cases、Neuroblastoma Research and Treatments、Soft tissue tumors and treatment

The light microscopic and ultrastructural features of 3 cases of malignant schwannoma were studied and compared with those of other types of soft-tissue sarcoma. The tumor in 1 of these cases originated in an intercostal nerve and was composed of compactly arranged spindle-shaped tumor cells. The other 2 cases showed osteogenic areas in addition to exhibiting prominent nuclear palisading, focal myxoid changes, and a rosette-like arrangement of tumor cells. The tumor in 1 of these latter cases occurred at the site of a preexisting neurofibroma. The Schwann cell origin of these tumors is strongly supported by the ultrastructural findings of basement membranes and conspicuous intercellular junctions in all 3 cases and dense-core granules in 1.