Elimination of New Chronic Hepatitis B Virus Infections: Results of the Alaska Immunization Program

作者：Rafael Harpaz, Brian J. McMahon, Harold S. Margolis, Craig N. Shapiro, Dean Havron, Gina Carpenter, LISA R. BULKOW, Robert B. Wainwright · 发表于：The Journal of Infectious Diseases · 年份：2000 · DOI：10.1086/315259 · 被引用次数：156 · 研究领域：Hepatitis B Virus Studies、Vaccine Coverage and Hesitancy、Hepatitis Viruses Studies and Epidemiology

An immunization assessment and a serologic survey were conducted to evaluate the effectiveness of a hepatitis B immunization program in eliminating hepatitis B virus (HBV) transmission among Alaska Natives in a region in which HBV infection is endemic. Hepatitis B vaccine coverage was 93% among 567 children </=10 years old residing in the study villages, and catch-up vaccine coverage among 582 susceptible persons 11-30 years old was 62%. None of 271 tested children </=10 years old were chronically infected with HBV, and just 4 (1.5%) had evidence of resolved infection. In contrast, 16% of 332 persons 11-30 years old (those born before implementation of routine infant hepatitis B vaccination) were chronically infected. A hepatitis B immunization program that includes prevention of perinatal HBV infection, routine infant vaccination, and catch-up vaccination of older children and adults can eliminate new chronic HBV infections in a population with a high rate of chronic infection.