Nonphotic Phase Shifting in Hamster Clock Mutants

作者：Nicholas Mrosovsky, Peggy A. Salmon, Michael Menaker, Martin Roland Ralph · 发表于：Journal of Biological Rhythms · 年份：1992 · DOI：10.1177/074873049200700104 · 被引用次数：85 · 研究领域：Circadian rhythm and melatonin、Photoreceptor and optogenetics research、Neural dynamics and brain function

Golden hamsters with the tau mutation were kept in the dark and induced to become active through confinement to a novel running wheel for 3 hr. The response of the mutants to this nonphotic phase-shifting stimulus differed from that of wild-type hamsters. The mutants showed larger phase shifts, and their phase response curves differed in shape, with an advance portion at about circadian time 24, a phase at which wild types show delays. The results establish that the tau mutation, in addition to its already known effects, alters the response of the circadian system to nonphotic events.