Evolving concepts in the systemic adjuvant treatment of breast cancer.

作者：Gianni Bonadonna · 发表于：PubMed · 年份：1992 · 被引用次数：112 · 研究领域：Cancer Treatment and Pharmacology、Breast Cancer Treatment Studies、HER2/EGFR in Cancer Research

This paper will review the evolution of scientific concepts underlying major clinical trials undertaken since the early 1970s with systemic adjuvant and neoadjuvant treatments for resect able breast cancer. To protect the readers from the deluge of reports that have appeared in the medical literature on the subject in question, this review will purposely avoid dissecting individual studies. Rather, on the basis of important treatment findings, it will attempt to provide a guide as how the strategic approach has been progressively changing in the effort to im prove the control of high risk breast cancer.