Body Mass Index and Risk of Gastric Cancer: A Meta-analysis

作者：Xiaojun Lin, Cheng‐Ping Wang, X.-D. Liu, X.-D. Liu, K.K. Yan, S. Li, H.-H. Bao, L.-Y. Zhao, X. Liu, X. Liu · 发表于：Japanese Journal of Clinical Oncology · 年份：2014 · DOI：10.1093/jjco/hyu082 · 被引用次数：118 · 研究领域：Cancer Risks and Factors、Helicobacter pylori-related gastroenterology studies、Gastric Cancer Management and Outcomes

OBJECTIVE: Overweight and obesity, indicated as increased body mass index, are associated with the risk of some cancers. We carried out a meta-analysis on published cohort and case-control studies to assess the strength of association between body mass index and gastric cancer. METHODS: Relevant studies were identified through PubMed, Web of Science and Medline electronic databases. Adjusted relative risks (odds ratios) with 95% confidence interval were used to assess the strength of association between body mass index and gastric cancer. RESULTS: Sixteen eligible studies were included in this meta-analysis. Overall, obesity (body mass index ≥ 30 kg/m(2)) was associated with an increased risk of gastric cancer (odds ratio = 1.13, 95% confidence interval = 1.03-1.24) compared with normal weight (body mass index = 18.5 to <25 kg/m(2)), while overweight (body mass index = 18.5 to <30 kg/m(2)) showed no association (odds ratio = 1.04, 95% confidence interval = 0.96-1.12). Specifically, a stratified analysis showed there were associations between obesity and the increased risk of gastric cancer for males (odds ratio = 1.27, 95% confidence interval = 1.09-1.48), non-Asians (odds ratio = 1.14, 95% confidence interval = 1.02-1.28) and both cohort studies (odds ratio = 1.10, 95% confidence interval = 1.00-1.22) and case-control studies (odds ratio = 1.29, 95% confidence interval = 1.03-1.60). Both overweight (odds ratio = 1.22, 95% confidence interval = 1.05-1.42) and obesity (odds ra...