Advances in Urinary Proteome Analysis and Biomarker Discovery

作者：Danilo Fliser, Jan Novák, Visith Thongboonkerd, A[Combining Grave Accent]ngel Argile[Combining Acute Accent]s, Vera Jankowski, Mark Girolami, Joachim Jankowski, Harald Mischak · 发表于：Journal of the American Society of Nephrology · 年份：2007 · DOI：10.1681/asn.2006090956 · 被引用次数：288 · 研究领域：Advanced Proteomics Techniques and Applications、Chronic Kidney Disease and Diabetes、Metabolomics and Mass Spectrometry Studies

Noninvasive diagnosis of kidney diseases and assessment of the prognosis are still challenges in clinical nephrology. Definition of biomarkers on the basis of proteome analysis, especially of the urine, has advanced recently and may provide new tools to solve those challenges. This article highlights the most promising technological approaches toward deciphering the human proteome and applications of the knowledge in clinical nephrology, with emphasis on the urinary proteome. The data in the current literature indicate that although a thorough investigation of the entire urinary proteome is still a distant goal, clinical applications are already available. Progress in the analysis of human proteome in health and disease will depend more on the standardization of data and availability of suitable bioinformatics and software solutions than on new technological advances. It is predicted that proteomics will play an important role in clinical nephrology in the very near future and that this progress will require interactive dialogue and collaboration between clinicians and analytical specialists.