Transcriptome network-based method to identify genes associated with unruptured intracranial aneurysms

作者：Liang Wei, Yujiao Gao, Shuxu Wei, Yuanyuan Zhang, W.F. Zhang, Jinfa Jiang, Zeao Sun, Weipeng Xu · 发表于：Genetics and Molecular Research · 年份：2013 · DOI：10.4238/2013.september.3.2 · 被引用次数：4 · 研究领域：Intracranial Aneurysms: Treatment and Complications、Ferroptosis and cancer prognosis、S100 Proteins and Annexins

Intracranial aneurysm is a balloon or sac-like dilatation of blood vessels inside the brain. Despite their importance, the biological mechanisms of intracranial aneurysms are not totally understood. We used public genome-wide gene expression profile data to identify potential genes that are involved in intracranial aneurysm in order to construct a regulation network. Some of the transcription factors and target genes that we identified in this network had been identified as related to intracranial aneurysm in previous studies. We found additional transcription factors and target genes that are apparently related to intracranial aneurysm with this method. The confirmation of previously identified genes and transcription factors supports the usefulness of this transcriptome network analysis for the identification of candidate genes involved in intracranial aneurysm.