Combined photodynamic and low-level laser therapies as an adjunct to nonsurgical treatment of chronic periodontitis

作者：Jane Ching-Lam Lui, EF Corbet, LJ Jin · 发表于：Journal of Periodontal Research · 年份：2010 · DOI：10.1111/j.1600-0765.2010.01316.x · 被引用次数：124 · 研究领域：Laser Applications in Dentistry and Medicine、Oral microbiology and periodontitis research、Photodynamic Therapy Research Studies

BACKGROUND AND OBJECTIVE: In recent years, there has been a growing interest in the use of dental lasers for treatment of periodontal diseases. The purpose of this short-term clinical trial was to evaluate the effects of a combination of photodynamic therapy with low-level laser therapy as an adjunct to nonsurgical treatment of chronic periodontitis. MATERIAL AND METHODS: Twenty-four nonsmoking adults with untreated chronic periodontitis were randomly assigned in a split-mouth design to receive scaling and root debridement with or without one course of adjunctive photodynamic therapy and low-level laser therapy within 5 d. Plaque, bleeding on probing, probing depth and gingival recession were recorded at baseline, 1 and 3 mo after the treatment. Gingival crevicular fluid was collected for assay of interleukin-1β levels at baseline, 1 wk and 1 mo. RESULTS: The test teeth achieved greater reductions in the percentage of sites with bleeding on probing and in mean probing depth at 1 mo compared with the control teeth (p < 0.05). A significant decrease in gingival crevicular fluid volume was observed in both groups at 1 wk (p < 0.001), with a further decrease at 1 mo in the test sites (p < 0.05). The test sites showed a greater reduction of interleukin-1β levels in gingival crevicular fluid at 1 wk than the control sites (p < 0.05). No significant differences in periodontal parameters were found between the test and control teeth at 3 mo. CONCLUSIONS: The present study suggests th...