Mechanism of Deep Brain Stimulation

作者：Satomi Chiken, Atsushi Nambu · 发表于：The Neuroscientist · 年份：2015 · DOI：10.1177/1073858415581986 · 被引用次数：384 · 研究领域：Neurological disorders and treatments、Parkinson's Disease Mechanisms and Treatments、Neuroscience and Neural Engineering

Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain structures, has now provided an effective therapeutic option for treatment of various neurological and psychiatric disorders. DBS targeting the internal segment of the globus pallidus, subthalamic nucleus, and thalamus is used to treat symptoms of movement disorders, such as Parkinson's disease, dystonia, and tremor. However, the mechanism underlying the beneficial effects of DBS remains poorly understood and is still under debate: Does DBS inhibit or excite local neuronal elements? In this short review, we would like to introduce our recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.