Interleukin 10 Increases CCR5 Expression and HIV Infection in Human Monocytes

作者：Silvano Sozzani, Silvia Ghezzi, Gioacchin Iannolo, Walter Luini, Alessandro Borsatti, Nadia Polentarutti, Antonio Sica, Massimo Locati, Charles Reay Mackay, Timothy N. C. Wells, Priscilla Biswas, Elisa Vicenzi, Guido Poli, Alberto Mantovani · 发表于：The Journal of Experimental Medicine · 年份：1998 · DOI：10.1084/jem.187.3.439 · 被引用次数：232 · 研究领域：HIV Research and Treatment、Immune Cell Function and Interaction、Chemokine receptors and signaling

The immunosuppressive and antiinflammatory cytokine interleukin (IL) 10 selectively upregulates the expression of the CC chemokine receptors CCR5, 2, and 1 in human monocytes by prolonging their mRNA half-life. IL-10-stimulated monocytes display an increased number of cell surface receptors for, and better chemotactic responsiveness to, relevant agonists than do control cells. In addition, IL-10-stimulated monocytes are more efficiently infected by HIV BaL. This effect was associated to the enhancement of viral entry through CCR5. These data add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.