In Vitro Permeation Studies of Nanoemulsions Containing Ketoprofen as a Model Drug

作者：Beom‐Su Kim, Myoung Won, Yang Yang, Kang Min Lee, C. S Kim · 发表于：Drug Delivery · 年份：2008 · DOI：10.1080/10717540802328599 · 被引用次数：84 · 研究领域：Advancements in Transdermal Drug Delivery、Advanced Drug Delivery Systems、Surfactants and Colloidal Systems

We prepared a nanoemulsion system with benzyl alcohol/ ethanol/Solutol/smash(R) HS 15 /water. Ketoprofen was used as a model drug in this study. The nanoemulsions of this system evidenced a high degree of stability. The droplet diameter did not change over a period of at least 3 months. The nanoemulsion containing 4% benzyl alcohol evidenced a permeation rate higher than was observed with the 1% and 2% nanoemulsions. Also the nanoemulsion containing 1% Solutol(R) HS 15 provided a permeation rate higher than was seen with the 2% and 4% nanoemulsions. All ketoprofen-loaded nanoemulsions enhanced the in vitro permeation rate through mouse skins as compared to the control.