Cerebral amyloid angiopathy related inflammation: three case reports and a review

作者：KongKhi Chung, N. E. Anderson, David Hutchinson, Beth J. Synek, P. Alan Barber · 发表于：Journal of Neurology Neurosurgery & Psychiatry · 年份：2010 · DOI：10.1136/jnnp.2009.204180 · 被引用次数：235 · 研究领域：Intracerebral and Subarachnoid Hemorrhage Research、Amyloidosis: Diagnosis, Treatment, Outcomes、Alzheimer's disease research and treatments

Cerebral amyloid angiopathy related inflammation (CAA-I), previously described under various names, is a treatable encephalopathy usually occurring in older adults. Here, three patients are described with histopathologically confirmed CAA-I, and summarised data from the published literature are presented. CAA-I has a characteristic combination of clinical and radiological features. Definite diagnosis requires brain and leptomeningeal biopsy. A favourable response to immunosuppressive therapy is common and treatment without brain biopsy may be considered in selected patients. Diagnostic criteria for CAA-I are proposed.