Whole-Exome Sequencing Identifies Rare and Low-Frequency Coding Variants Associated with LDL Cholesterol

作者：Leslie A. Lange, Youna Hu, He Zhang, Chenyi Xue, Ellen M. Schmidt, Zheng-Zheng Tang, Chris Bizon, Ethan M. Lange, Joshua D. Smith, Emily H. Turner, Goo Jun, Hyun Min Kang, Gina M. Peloso, Paul L. Auer, Kuo-ping Li, Jason Flannick, Ji Zhang, Christian Fuchsberger, Kyle J. Gaulton, Cecilia M. Lindgren, Adam E. Locke, Alisa K. Manning, Xueling Sim, Manuel A. Rivas, Oddgeir L. Holmen, Omri Gottesman, Yingchang Lu, Douglas M. Ruderfer, Eli A. Stahl, Qing Duan, Yun Li, Peter Durda, Shuo Jiao, Aaron Isaacs, Albert Hofman, Joshua C. Bis, Adolfo Correa, Michael Griswold, Jóhanna Jakobsdóttir, Albert V. Smith, Pamela J. Schreiner, Mary F. Feitosa, Qunyuan Zhang, Jennifer E. Huffman, Jacy R. Crosby, Christina L. Wassel, Ron Do, Nora Franceschini, Lisa W. Martin, Jennifer G. Robinson, Themistocles L. Assimes, David R. Crosslin, Elisabeth A. Rosenthal, Michael Y. Tsai, Mark J. Rieder, Deborah Farlow, Aaron R. Folsom, Thomas Lumley, Ervin R. Fox, Christopher S. Carlson, Ulrike Peters, Rebecca D. Jackson, Cornelia M. van Duijn, André G. Uitterlinden, Daniel Levy, Jerome I. Rotter, Herman A. Taylor, Vilmundur Guðnason, David S. Siscovick, Myriam Fornage, Ingrid B. Borecki, Caroline Hayward, Igor Rudan, Y. Eugene Chen, Erwin P. Böttinger, Ruth J. F. Loos, Pål Sætrom, Kristian Hveem, Michael Boehnke, Leif Groop, Mark I. McCarthy, Thomas Meitinger, Christie M. Ballantyne, Stacey Gabriel, Christopher J. O’Donnell, Wendy S. Post, Kari E. North, Alexander P. Reiner, Eric Boerwinkle, Bruce M. Psaty, David Altshuler, Sekar Kathiresan, Dan-Yu Lin, Gail P. Jarvik, L. Adrienne Cupples, Charles Kooperberg, James G. Wilson, Deborah A. Nickerson, Gonçalo R. Abecasis, Stephen S. Rich, Russell P. Tracy, Cristen J. Willer, Stacey Gabriel, David Altshuler, Gonçalo R. Abecasis, Hooman Allayee, Sharon Cresci, Mark J. Daly, Paul I. W. de Bakker, Mark A. DePristo, Ron Do, Peter Donnelly, Deborah Farlow, Tim Fennell, Kiran Garimella, Stanley L. Hazen, Youna Hu, Daniel M. Jordan, Goo Jun, Sekar Kathiresan, Hyun Min Kang, Adam Kieżun, Guillaume Lettre, Bingshan Li, Mingyao Li, Christopher Newton‐Cheh, Sandosh Padmanabhan, Gina M. Peloso, Sara L. Pulit, Daniel J. Rader, David Reich, Muredach P. Reilly, Manuel A. Rivas, Steven M. Schwartz, Laura J. Scott, David S. Siscovick, John A. Spertus, Nathaniel O. Stitziel, Nina Stoletzki, Shamil Sunyaev, Benjamin F. Voight, Cristen J. Willer, Stephen S. Rich, Ermeg L. Akylbekova, Larry D. Atwood, Christie M. Ballantyne, Maja Barbalić, R. Graham Barr, Emelia J. Benjamin, Joshua C. Bis, Eric Boerwinkle, Donald W. Bowden, Jennifer A. Brody, Matthew J. Budoff, Greg Burke, Sarah G. Buxbaum, Jeff Carr, Donna T. Chen, Ida Y. Chen, Wei‐Min Chen, Patrick Concannon, Jacy R. Crosby, L. Adrienne Cupples, Ralph B. D’Agostino, Anita L. DeStefano, Albert W. Dreisbach, Josée Dupuis, Jon Peter Durda, Jaclyn Ellis, Aaron R. Folsom, Myriam Fornage, Caroline S. Fox, Ervin R. Fox, Vincent Funari, Santhi K. Ganesh, Julius M. Gardin, David C. Goff, Ora Gordon, Wayne W. Grody, Myron Gross, Xiuqing Guo, Ira M. Hall, Nancy L. Heard‐Costa, Susan R. Heckbert, Nicholas H. Heintz, David M. Herrington, DeMarc A. Hickson, Jie Huang, Shih‐Jen Hwang, David R. Jacobs, Nancy S. Jenny, Andrew D. Johnson, Craig Johnson, Steven M. Kawut, Richard A. Kronmal, Raluca Kurz, Ethan M. Lange, Leslie A. Lange, Martin G. Larson, Mark Lawson, Cora E. Lewis, Daniel Levy, Dalin Li, Honghuang Lin, Chunyu Liu, Jiankang Liu, Kiang Liu, Xiaoming Liu, Ching‐Ti Liu, W.T. Longstreth, Cay Loria, Thomas Lumley, Kathryn L. Lunetta, Aaron J. Mackey, Rachel H. Mackey, Ani Manichaikul, Taylor J. Maxwell, Barbara McKnight, James B. Meigs, Alanna C. Morrison, Solomon K. Musani, Josyf C. Mychaleckyj, Jennifer A. Nettleton, Kari E. North, Christopher J. O’Donnell, Daniel S. OʼLeary, Frank S Ong, Walter Palmas, James S. Pankow, Nathan Pankratz, Shom Paul, Marco Pérez, Sharina D. Person, Joseph F. Polak, Wendy S. Post, Bruce M. Psaty, Aaron R. Quinlan, Leslie J. Raffel, Ramachandran S. Vasan, Alex P. Reiner, Kenneth Rice, Jerome I. Rotter, Jill P. Sanders, Pamela J. Schreiner, Sudha Seshadri, Steve Shea, Stephen Sidney, Kevin A.T. Silverstein, Nicholas L. Smith, Nona Sotoodehnia, Asoke Srinivasan, Herman A. Taylor, Kent D. Taylor, Fridtjof Thomas, Russell P. Tracy, Michael Y. Tsai, Kelly A. Volcik, Chrstina L. Wassel, Karol Watson, Gina S. Wei, Wendy White, Kerri L. Wiggins, Jemma B. Wilk, O. Dale Williams, G. Wilson, James G. Wilson, Phillip Wolf, Neil A. Zakai, John Hardy, James F. Meschia, Michael A. Nalls, Andrew B. Singleton, Brad Worrall, Michael J. Bamshad, Kathleen C. Barnes, Ibrahim Abdulhamid, Frank J. Accurso, Ran D. Anbar, Terri Beaty, Abigail W. Bigham, Phillip Black, Eugene R. Bleecker, Kati J. Buckingham, Anne Marie Cairns, Daniel B. Caplan, Barbara A. Chatfield, Aaron Chidekel, Michael Cho, David C. Christiani, James D. Crapo, Julia M. Crouch, Denise Daley, Anthony T. Dang, Hong Dang, Alicia De Paula, J. DeCelie-Germana, Allen DozorMitch Drumm, Maynard Dyson, Julia Emerson, Mary J. Emond, Thomas W. Ferkol, Robert Fink, Cassandra Foster, Deborah Froh, Li Gao, William M. Gershan, Ronald L. Gibson, Elizabeth Godwin, Magdalen Gondor, Héctor Gutiérrez, Nadia N. Hansel, Paul M. Hassoun, Peter Hiatt, John E. Hokanson, Michelle S. Howenstine, Laura K. Hummer, Jamshed F. Kanga, Yoonhee Kim, Michael R. Knowles, Michael W. Konstan, Thomas Lahiri, Nan M. Laird, Christoph Lange, Lin Lin, Xihong Lin, Tin L. Louie, David R. Lynch, Barry J. Make, Thomas R. Martin, Steve C. Mathai, Rasika A. Mathias, John McNamara, Sharon McNamara, Deborah A. Meyers, Susan L. Millard, Peter J. Mogayzel, Richard B. Moss, Tanda Murray, Dennis W. Nielson, Blakeslee E. Noyes, Wanda K. O’Neal, David Orenstein, Brian O’Sullivan, Rhonda G. Pace, Peter D. Paré, H. Worth Parker, Mary Ann Passero, Elizabeth A. Perkett, Adrienne Prestridge, Nicholas Rafaels, Bonnie Ramsey, Elizabeth A. Regan, Clement L. Ren, George Retsch‐Bogart, Michael J. Rock, Antony Rosen, Margaret Rosenfeld, Ingo Ruczinski, Andrew Sanford, David J. Schaeffer, Cindy Sell, Daniel P. Sheehan, Edwin K. Silverman, Don D. Sin, Terry Spencer, J. Stonebraker, Holly K. Tabor, Laurie Varlotta, Candelaria Vergara, Robert Weiss, Fred Wigley, Robert A. Wise, Fred A. Wright, Mark M. Wurfel, Robert Zanni, Fei Zou, Deborah A. Nickerson, Mark J. Rieder, Phil Green, Jay Shendure, Joshua M. Akey, Carlos D. Bustamante, David R. Crosslin, Evan E. Eichler, Phillips Fox, Wenqing Fu, Allan Gordon, Simon Gravel, Gail P. Jarvik, Jill M. Johnsen, Mengyuan Kan, Eimear E. Kenny, Jeffrey M. Kidd, Fremiet Lara-Garduno, Suzanne M. Leal, Dajiang J. Liu, Sean McGee, Timothy D. O’Connor, Bryan Paeper, Peggy D. Robertson, Joshua D. Smith, Jeffrey Staples, Jacob A. Tennessen, Emily H. Turner, Gao Wang, Yi Qian, Rebecca D. Jackson, Ulrike Peters, Christopher S. Carlson, Garnet L. Anderson, Hoda Anton‐Culver, Themistocles L. Assimes, Paul L. Auer, Shirley A.A. Beresford, Chris Bizon, Henry R. Black, Robert L. Brunner, Robert G. Brzyski, Dale R. Burwen, Bette J. Caan, Cara L. Carty, Rowan T. Chlebowski, Steven R. Cummings, J. David Curb, Charles B. Eaton, Leslie Ford, Nora Franceschini, Stephanie M. Fullerton, Margery Gass, Nancy L. Geller, Gerardo Heiss, Barbara V. Howard, Li Hsu, Carolyn M. Hutter, John P. A. Ioannidis, Shuo Jiao, Karen Johnson, Charles Kooperberg, Lewis Kuller, Andrea Z. LaCroix, Kamakshi Lakshminarayan, Dorothy S. Lane, Norman L. Lasser, Erin S. LeBlanc, Kuo-ping Li, Marian C. Limacher, Dan-Yu Lin, Benjamin A. Logsdon, Shari Ludlam, JoAnn E. Manson, Karen L. Margolis, Lisa W. Martin, Joan McGowan, Keri L. Monda, Jane Morley Kotchen, Lauren Nathan, Judith K. Ockene, Mary Jo O’Sullivan, Lawrence S. Phillips, Ross L. Prentice, John Robbins, Jennifer G. Robinson, Jacques E. Rossouw, Haleh Sangi‐Haghpeykar, Gloria E. Sarto, Sally A. Shumaker, Michael S. Simon, Marcia L. Stefanick, Evan A. Stein, Hua Tang, Kira C. Taylor, Cynthia A. Thomson, Timothy A. Thornton, Linda Van Horn, Mara Z. Vitolins, Jean Wactawski‐Wende, Robert W. Wallace, Sylvia Wassertheil‐Smoller, Donglin Zeng, Deborah Applebaum‐Bowden, Michael Feolo, Weiniu Gan, Dina N. Paltoo, Phyliss Sholinsky, Anne Sturcke · 发表于：The American Journal of Human Genetics · 年份：2014 · DOI：10.1016/j.ajhg.2014.01.010 · 被引用次数：217 · 研究领域：Genetic Associations and Epidemiology、Lipoproteins and Cardiovascular Health、RNA Research and Splicing