General Catalysts for the Suzuki–Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water

作者：Kevin W. Anderson, Stephen L. Buchwald · 发表于：Angewandte Chemie International Edition · 年份：2005 · DOI：10.1002/anie.200502017 · 被引用次数：400 · 研究领域：Catalytic Cross-Coupling Reactions、Catalytic C–H Functionalization Methods、Chemical Synthesis and Analysis

Amphiphilic phosphine ligands (see structures; Cy=cyclohexyl) were prepared and utilized in palladium-catalyzed Suzuki–Miyaura and Sonogashira coupling reactions in water or water/organic biphasic solvents, providing excellent yields of functionalized biaryls and aryl alkynes, respectively.