Developmental Changes in Organization of Structural Brain Networks

作者：Budhachandra S. Khundrakpam, Andrew Reid, Jens Bräuer, Félix Carbonell, John David Lewis, Stephanie Hope Ameis, Sherif Karama, Junki Lee, Zhang Chen, Samir Das, Alan Charles Evans, Brain Development Cooperative Group, William S. Ball, Anna W. Byars, Mark B. Schapiro, Wendy A. Bommer, April Carr, April German, Scott Dunn, Michael J. Rivkin, Deborah P. Waber, Robert V. Mulkern, Sridhar Vajapeyam, Abigail Chiverton, Peter E. Davis, Julie Koo, Jacki Marmor, Christine Mrakotsky, Richard L. Robertson, Gloria B. McAnulty, Michael E. Brandt, Jack McKay Fletcher, Larry A. Kramer, Grace Yang, Cara McCormack, Kathleen M. Hebert, Hilda Volero, Kelly N. Botteron, Robert C. McKinstry, William M. Warren, Tomoyuki Nishino, C. Robert Almli, Richard D. Todd, John Nicholas Constantino, James T. McCracken, Jennifer G. Levitt, Jeffrey Alger, Joseph O'Neil, Arthur W. Toga, Robert F. Asarnow, David Fadale, Laura Heinichen, Cedric Ireland, Dah-Jyuu Wang, E. Daniel Moss, Robert A. Zimmerman, Brooke Bintliff, Ruth M. Bradford, Janice Newman, Alan Charles Evans, Rozalia Arnaoutelis, G. Bruce Pike, D. Louis Collins, Gabriel T. Leonard, Tomáš Paus, Alex P. Zijdenbos, Samir Das, Vladimir Fonov, Luke Fu, Jonathan Harlap, Ilana Ruth Leppert, Denise L. Milovan, Dario Vins, Thomas Zeffiro, John van Meter, Nicholas DE LANGE, Michael P. Froimowitz, Kelly N. Botteron, C. Robert Almli, Cheryl A. Rainey, Stan Henderson, Tomoyuki Nishino, William M. Warren, Jennifer L. Edwards, Diane Dubois, Karla Smith, Tish Singer, Aaron A. Wilber, Carlo M. Pierpaoli, Peter J. Basser, Lin‐Ching Chang, Cheng Guan Koay, Lindsay Walker, Lisa S. Freund, Judith M. Rumsey, Lauren Baskir, Laurence Stanford, Karen Y. Sirocco, Katrina Gwinn, Giovanna M. Spinella, James T. McCracken, Jeffry R. Alger, Jennifer G. Levitt, Joseph O’Neill · 发表于：Cerebral Cortex · 年份：2012 · DOI：10.1093/cercor/bhs187 · 被引用次数：243 · 研究领域：Functional Brain Connectivity Studies、Neural dynamics and brain function、Advanced Neuroimaging Techniques and Applications

Recent findings from developmental neuroimaging studies suggest that the enhancement of cognitive processes during development may be the result of a fine-tuning of the structural and functional organization of brain with maturation. However, the details regarding the developmental trajectory of large-scale structural brain networks are not yet understood. Here, we used graph theory to examine developmental changes in the organization of structural brain networks in 203 normally growing children and adolescents. Structural brain networks were constructed using interregional correlations in cortical thickness for 4 age groups (early childhood: 4.8-8.4 year; late childhood: 8.5-11.3 year; early adolescence: 11.4-14.7 year; late adolescence: 14.8-18.3 year). Late childhood showed prominent changes in topological properties, specifically a significant reduction in local efficiency, modularity, and increased global efficiency, suggesting a shift of topological organization toward a more random configuration. An increase in number and span of distribution of connector hubs was found in this age group. Finally, inter-regional connectivity analysis and graph-theoretic measures indicated early maturation of primary sensorimotor regions and protracted development of higher order association and paralimbic regions. Our finding reveals a time window of plasticity occurring during late childhood which may accommodate crucial changes during puberty and the new developmental tasks that an a...