Abscopal regression of hepatocellular carcinoma after radiotherapy for bone metastasis

作者：Kazuo Ohba, Katsumi Omagari, Takashi Nakamura, Nobuhiro Ikuno, Sachiko Saeki, Isao Matsuo, Hideki Kinoshita, Junichi Masuda, Hiroaki Hazama, Ichiro Sakamoto, S Kohno · 发表于：Gut · 年份：1998 · DOI：10.1136/gut.43.4.575 · 被引用次数：276 · 研究领域：Management of metastatic bone disease、Hepatocellular Carcinoma Treatment and Prognosis、Advanced Radiotherapy Techniques

Spontaneous regression of hepatocellular carcinoma is a rare phenomenon. Abscopal regression of tumours resulting from the effect of irradiation of a tissue on a remote non-irradiated tissue is also rare. The case of a 76 year old Japanese man with hepatocellular carcinoma that regressed after radiotherapy for thoracic vertebral bone metastasis is described. Serum levels of tumour necrosis factor-alpha increased after radiotherapy. The findings suggests that such abscopal related regression may be associated with host immune response, involving cytokines such as tumour necrosis factor-alpha.