Role of bicyclol in preventing chemotherapeutic agent-induced liver injury in patients over 60 years of age with cancer

作者：Xiaoyuan Li, Jian-Feng Zhou, Shuchang Chen, Mei Guan, Yingyi Wang, Lin Zhao, Hongyan Ying, Yanping Zhou · 发表于：Journal of International Medical Research · 年份：2014 · DOI：10.1177/0300060514527058 · 被引用次数：33 · 研究领域：Cancer Treatment and Pharmacology、Chemotherapy-induced organ toxicity mitigation、Drug-Induced Hepatotoxicity and Protection

OBJECTIVE: To evaluate the efficacy of bicyclol in preventing chemotherapy-induced liver damage. METHODS: Patients ≥60 years of age with cancer were equally randomized into control (chemotherapy alone) or prophylactic (chemotherapy supplemented with 75 mg bicyclol, oral, daily) groups. Liver function indices were assessed immediately before treatment, during each therapy cycle and following treatment. RESULTS: Of 306 patients enrolled, 300 patiets completed the study (n = 147 and n = 153; prophylactic and control groups, respectively). Incidence of grade I-IV elevation of serum transaminase and/or bilirubin was significantly lower in the prophylactic group (17.1%) compared with the control group (47.1%). Incidence of grade II-IV hepatic injury was also significantly lower in the prophylactic group (0.7%) than in the control group (12.4%). CONCLUSIONS: Prophylactic bicyclol (75 mg daily) could significantly reduce the incidence and degree of chemotherapeutic agent-induced liver damage in elderly patients with cancer. Further studies are recommended with larger sample sizes and long-term follow up.