Immunobiology of Dendritic Cells

作者：Jacques Banchereau, Francine Brière, Christophe Caux, Jean Davoust, Serge Lebecque, Yongjun Liu, Bali Pulendran, Karolina Palucka · 发表于：Annual Review of Immunology · 年份：2000 · DOI：10.1146/annurev.immunol.18.1.767 · 被引用次数：6614 · 研究领域：Immunotherapy and Immune Responses、T-cell and B-cell Immunology、Immune Cell Function and Interaction

Dendritic cells (DCs) are antigen-presenting cells with a unique ability to induce primary immune responses. DCs capture and transfer information from the outside world to the cells of the adaptive immune system. DCs are not only critical for the induction of primary immune responses, but may also be important for the induction of immunological tolerance, as well as for the regulation of the type of T cell-mediated immune response. Although our understanding of DC biology is still in its infancy, we are now beginning to use DC-based immunotherapy protocols to elicit immunity against cancer and infectious diseases.