LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way

作者：Xi He, Mikhail Semenov, Keiko Tamai, Xin Zeng · 发表于：Development · 年份：2004 · DOI：10.1242/dev.01117 · 被引用次数：1047 · 研究领域：Wnt/β-catenin signaling in development and cancer、Cancer-related gene regulation、Connective tissue disorders research

Wnt signaling through the canonical beta-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/beta-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular beta-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.