Cohesin: Its Roles and Mechanisms

作者：Kim Nasmyth, Christian H. Haering · 发表于：Annual Review of Genetics · 年份：2009 · DOI：10.1146/annurev-genet-102108-134233 · 被引用次数：1001 · 研究领域：Genomics and Chromatin Dynamics、Microtubule and mitosis dynamics、DNA Repair Mechanisms

The cohesin complex is a major constituent of interphase and mitotic chromosomes. Apart from its role in mediating sister chromatid cohesion, it is also important for DNA double-strand-break repair and transcriptional control. The functions of cohesin are regulated by phosphorylation, acetylation, ATP hydrolysis, and site-specific proteolysis. Recent evidence suggests that cohesin acts as a novel topological device that traps chromosomal DNA within a large tripartite ring formed by its core subunits.