In Situ, Label‐Free DNA Detection Using Organic Transistor Sensors

作者：Hadayat Ullah Khan, Mark E. Roberts, Olasupo Johnson, Renate Förch, Wolfgang Knoll, Zhenan Bao · 发表于：Advanced Materials · 年份：2010 · DOI：10.1002/adma.201000790 · 被引用次数：186 · 研究领域：Organic Electronics and Photovoltaics、Conducting polymers and applications、Molecular Junctions and Nanostructures

Organic thin-film transistors modified with 15-base PNA strands are used for the selective detection of target DNA sequences. These simple devices provide a low-cost, label-free and in situ detection platform with excellent discrimination between single and double base mismatches in the target DNA sequence. The electronic detection signal is corroborated with conventional optical methods, displaying similar hybridization parameters.