Induction of the SOS response by new 4-quinolones

作者：Ian Richard Phillips, Esther Culebras, Felipe Moreno, Fernando Baquero · 发表于：Journal of Antimicrobial Chemotherapy · 年份：1987 · DOI：10.1093/jac/20.5.631 · 被引用次数：190 · 研究领域：Bacterial Genetics and Biotechnology、DNA and Nucleic Acid Chemistry、RNA and protein synthesis mechanisms

The 4-quinolones ciprofloxacin, difloxacin, enoxacin, norfloxacin, ofloxacin, and nalidixic acid were found to induce the SOS response in qualitative and quantitative tests on Escherichia coli K12 containing the sfiA::lacZ gene fusion. Maximum induction of the SOS-response was observed with the quinolone concentrations that produced the most killing. There was also a modest increase in the rate of mutation in the lactose and galactose operons in a GalE- background, provided there was a functioning SOS system.