Oxidative Decay of DNA

作者：Kenneth B. Beckman, Bruce N. Ames · 发表于：Journal of Biological Chemistry · 年份：1997 · DOI：10.1074/jbc.272.32.19633 · 被引用次数：952 · 研究领域：Carcinogens and Genotoxicity Assessment、DNA Repair Mechanisms、Free Radicals and Antioxidants

The study of DNA oxidation has progressed from an exploratory phase, during which its basic biochemistry was established, into a field branching out into numerous areas. Early on, radiation biologists discovered that radiolysis of water generates oxygen free radicals, which are responsible for many of the consequences of irradiating living things. The characterization of radiation-induced oxidative DNA lesions, and the connection between radiation and cancer, caused a surge of interest in DNA oxidationper se and raised the possibility of DNA damage from biological oxidants.