Adult neurogenesis in the decapod crustacean brain: a hematopoietic connection?

作者：Barbara S. Beltz, Yi Zhang, Jeanne L. Benton, D. C. Sandeman · 发表于：European Journal of Neuroscience · 年份：2011 · DOI：10.1111/j.1460-9568.2011.07802.x · 被引用次数：40 · 研究领域：Zebrafish Biomedical Research Applications、Neurobiology and Insect Physiology Research、Neurogenesis and neuroplasticity mechanisms

New neurons are produced and integrated into circuits in the adult brains of many organisms, including crustaceans. In some crustacean species, the first-generation neuronal precursors reside in a niche exhibiting characteristics analogous to mammalian neurogenic niches. However, unlike mammalian niches where several generations of neuronal precursors co-exist, the lineage of precursor cells in crayfish is spatially separated allowing the influence of environmental and endogenous regulators on specific generations in the neuronal precursor lineage to be defined. Experiments also demonstrate that the first-generation neuronal precursors in the crayfish Procambarus clarkii are not self-renewing. A source external to the neurogenic niche must therefore provide cells that replenish the first-generation precursor pool, because although these cells divide and produce a continuous efflux of second-generation cells from the niche, the population of first-generation niche precursors is not diminished with growth and aging. In vitro studies show that cells extracted from the hemolymph, but not other tissues, are attracted to and incorporated into the neurogenic niche, a phenomenon that appears to involve serotonergic mechanisms. We propose that, in crayfish, the hematopoietic system may be a source of cells that replenish the niche cell pool. These and other studies reviewed here establish decapod crustaceans as model systems in which the processes underlying adult neurogenesis, such a...