The self renewal probability of hemopoietic stem cells

作者：Helmut Vogel, Helgard Niewisch, G.T. Matioli · 发表于：Journal of Cellular Physiology · 年份：1968 · DOI：10.1002/jcp.1040720309 · 被引用次数：108 · 研究领域：Pluripotent Stem Cells Research、Renal and related cancers、3D Printing in Biomedical Research

Abstract The probability of a colony which originated as a single stem cell to become extinct due to differentiation of all of its stem cells in any generation is closely connected to stem cell self renewal probability p. p can be determined from the coefficient of variation of the colony numbers received by reinjecting single colonies of the same age. Whole spleens containing a known average colony number can also be used with advantage for this purpose. The results of both procedures indicate a stem cell self renewal probability p =0.62 ± 0.04, which does not change significantly between the sixth and the fourteenth day of colony development, and an extinction probability ω = 0.63 ± 0.12.