Cloning of a Novel Gene for Quinolone Resistance from a Transferable Plasmid in Shigella flexneri 2b

作者：Mami Hata, Masahiro Suzuki, Masakado Matsumoto, Masao Takahashi, Katsuhiko Sato, Shiro Ibe, Kenji Sakae · 发表于：Antimicrobial Agents and Chemotherapy · 年份：2005 · DOI：10.1128/aac.49.2.801-803.2005 · 被引用次数：292 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotics Pharmacokinetics and Efficacy、Cancer therapeutics and mechanisms

A novel gene for quinolone resistance was cloned from a transferable plasmid carried by a clinical isolate of Shigella flexneri 2b that was resistant to fluoroquinolones. The plasmid conferred low-level resistance to quinolones on Escherichia coli HB101. The protein encoded by the gene showed 59% amino acid identity with Qnr.