TQ inhibits hepatocellular carcinoma growth in vitro and in vivo via repression of Notch signaling

作者：Xiquan Ke, Yan Zhao, Xinlan Lu, Zhe Wang, Yuanyuan Liu, Mudan Ren, Guifang Lu, Dan Zhang, Zhenguo Sun, Zhipeng Xu, Jee Hoon Song, Yulan Cheng, Stephen J. Meltzer, Shuixiang He · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.5362 · 被引用次数：40 · 研究领域：Cancer Mechanisms and Therapy、Developmental Biology and Gene Regulation、Natural Compounds in Disease Treatment

// Xiquan Ke 1 , Yan Zhao 1 , Xinlan Lu 1 , Zhe Wang 2 , Yuanyuan Liu 3 , Mudan Ren 1 , Guifang Lu 1 , Dan Zhang 1 , Zhenguo Sun 4 , Zhipeng Xu 5 , Jee Hoon Song 6 , Yulan Cheng 6 , Stephen J. Meltzer 6 , Shuixiang He 1 1 Department of Gastroenterology, the First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi 710061, P.R. China 2 Department of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai 200065, P.R. China 3 Department of Gastroenterology, Xi’an Central Hospital, Xi’an, Shaanxi 710000, P.R. China 4 Department of Thoracic Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, P.R. China 5 Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China 6 Division of Gastroenterology, Departments of Medicine and Oncology and Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA Correspondence to: Shuixiang He, e-mail: hesx123@gmail.com Stephen J. Meltzer, e-mail: smeltzer@jhmi.edu Keywords: thymoquinone, hepatocellular carcinoma, Notch, cell cycle, apoptosis Received: May 29, 2015      Accepted: September 10, 2015      Published: September 21, 2015 ABSTRACT Thymoquinone (TQ) has been reported to possess anti-tumor activity in various types of cancer. However, its ...