Induction of protective immunity to monoclonal-antibody-defined Plasmodium falciparum antigens requires strong adjuvant in Aotus monkeys

作者：Wasim A. Siddiqui, L Q Tam, Siu-Chow Kan, Kenton J. Kramer, S E Case, K. Palmer, Karen M. Yamaga, George S. N. Hui · 发表于：Infection and Immunity · 年份：1986 · DOI：10.1128/iai.52.1.314-318.1986 · 被引用次数：58 · 研究领域：Malaria Research and Control、Aquaculture disease management and microbiota、Computational Drug Discovery Methods

Monoclonal antibodies to the major Plasmodium falciparum merozoite surface coat and rhoptry antigens were produced. A combination of the affinity-purified polypeptides with Freund complete adjuvant which was given three times completely protected an Aotus lemurinus azure (karotype VI) monkey against homologous challenge; however, immunization with the same polypeptides with a muramyl dipeptide derivative [MDP-Lys(L18)] did not protect a second Aotus monkey, even though comparable high antibody titers were induced.