Utility of a 0.014″ pressure‐sensing guidewire to assess renal artery translesional systolic pressure gradients

作者：William R. Colyer, Christopher J. Cooper, Mark W. Burket, William J. Thomas · 发表于：Catheterization and Cardiovascular Interventions · 年份：2003 · DOI：10.1002/ccd.10508 · 被引用次数：62 · 研究领域：Renal and Vascular Pathologies、Cerebrovascular and Carotid Artery Diseases、Advanced X-ray and CT Imaging

Renal ischemia due to renal artery stenosis (RAS) is an important cause of secondary hypertension and renal insufficiency. Several methods are available to diagnose RAS; however, the identification of clinically significant lesions remains problematic. We measured the translesional systolic pressure gradient (TSPG) with a 4 Fr catheter and a 0.014" pressure-sensing guidewire and compared these data to angiographic findings. The TSPG obtained by pressure-sensing guidewire correlated more strongly with angiographic minimal lumen diameter (r(2) = 0.801) than those obtained by 4 Fr catheter (r(2) = 0.360). The relationship of TSPG with percent stenosis was not strong, regardless of the method used (r(2) = 0.228 with pressure-sensing guidewire, 0.358 with 4 Fr catheter). Using a 0.014" pressure-sensing guidewire is effective for assessing TSPG and provides a more reliable indication of stenosis significance than use of a 4 Fr catheter.