ADPRT Val762Ala and XRCC1 Arg194Trp Polymorphisms and Risk of Gastric Cancer in Sichuan of China

作者：Yuan-Yuan Wen, Xiong‐Fei Pan, Marie Loh, Zhi Tian, Shujuan Yang, Sihan Lv, Wenzhi Huang, He Huang, Yao Xie, Richie Soong, Chun-Xia Yang · 发表于：Asian Pacific Journal of Cancer Prevention · 年份：2012 · DOI：10.7314/apjcp.2012.13.5.2139 · 被引用次数：31 · 研究领域：DNA Repair Mechanisms、Acute Lymphoblastic Leukemia research、Colorectal Cancer Treatments and Studies

OBJECTIVE: Gastric cancer remains a major health problem in China. We hypothesized that XRCC1 Arg194Trp and ADPRT Val762Ala may be associated with risk. METHODS: We designed a multicenter 1:1 matched case- control study of 307 pairs of gastric cancers and controls between October 2010 and August 2011. XRCC1 Arg194Trp and ADPRT Val762Ala were sequenced, and demographic data as well as lifestyle factors were collected using a self-designed questionnaire. RESULTS: Individuals carrying XRCC1 Trp/Trp or Arg/Trp variant genotype had a significantly increased risk of gastric cancer (OR, 1.718; 95% CI, 1.190-2.479), while the OR for ADPRT Val762Ala variant genotype (Ala/Ala or Val/Ala) was 1.175 (95% CI, 0.796-1.737). No gene-gene or gene-environment interactions were found. In addition, family history of cancer and drinkers proportion were higher among cases than among controls (P<0.05). CONCLUSIONS: XRCC1 194 Arg/Trp or Trp/Trp genotype, family history of cancer, and drinking are suspected risk factors of gastric cancer from our study. Our findings may offer insight into further similar large gene-environment and gene-gene studies in this region.