SURVEY AND SUMMARY Transcription by RNA polymerases I and III

作者：Marvin R. Paule · 发表于：Nucleic Acids Research · 年份：2000 · DOI：10.1093/nar/28.6.1283 · 被引用次数：504 · 研究领域：Genomics and Chromatin Dynamics、RNA and protein synthesis mechanisms、RNA Research and Splicing

The task of transcribing nuclear genes is shared between three RNA polymerases in eukaryotes: RNA polymerase (pol) I synthesizes the large rRNA, pol II synthesizes mRNA and pol III synthesizes tRNA and 5S rRNA. Although pol II has received most attention, pol I and pol III are together responsible for the bulk of transcriptional activity. This survey will summarise what is known about the process of transcription by pol I and pol III, how it happens and the proteins involved. Attention will be drawn to the similarities between the three nuclear RNA polymerase systems and also to their differences.