Reactive Oxygen Species–Mediated Mitochondria-to-Nucleus Signaling: A Key to Aging and Radical-Caused Diseases

作者：Peter Störz · 发表于：Science s STKE · 年份：2006 · DOI：10.1126/stke.3322006re3 · 被引用次数：142 · 研究领域：Mitochondrial Function and Pathology、Genetics, Aging, and Longevity in Model Organisms、Coenzyme Q10 studies and effects

Mitochondria-generated reactive oxygen species have been implicated as a common feature that connects aging of organisms and age-related diseases. Efficient elimination of these radicals by antioxidants correlates with increased life span. Understanding how the mitochondrion signals to the nucleus to regulate antioxidant proteins might be a key to aging processes and treatment of human diseases.