Mouse Plasmacytoid Cells

作者：Meredith A O’Keeffe, Hubertus Hochrein, David Vremec, Irina Caminschi, Joanna L. Miller, E. Margot Anders, Li Wu, Mireille Hanna Lahoud, Sandrine Henri, Bernadette Scott, Paul J. Hertzog, Liliana Tatarczuch, Ken Shortman · 发表于：The Journal of Experimental Medicine · 年份：2002 · DOI：10.1084/jem.20021031 · 被引用次数：369 · 研究领域：Immunotherapy and Immune Responses、T-cell and B-cell Immunology、Immune Response and Inflammation

The CD45RA(hi)CD11c(int) plasmacytoid predendritic cells (p-preDCs) of mouse lymphoid organs, when stimulated in culture with CpG or influenza virus, produce large amounts of type I interferons and transform without division into CD8(+)CD205(-) DCs. P-preDCs express CIRE, the murine equivalent of DC-specific intercellular adhesion molecule 3 grabbing nonintegrin (DC-SIGN). P-preDCs are divisible by CD4 expression into two subgroups differing in turnover rate and in response to Staphylococcus aureus. The kinetics of bromodeoxyuridine labeling and the results of transfer to normal recipient mice indicate that CD4(-) p-preDCs are the immediate precursors of CD4(+) p-preDCs. Similar experiments indicate that p-preDCs are normally long lived and are not the precursors of the short-lived steady-state conventional DCs. However, in line with the culture studies on transfer to influenza virus-stimulated mice the p-preDCs transform into CD8(+)CD205(-) DCs, distinct from conventional CD8(+)CD205(+) DCs. Hence as well as activating preexistant DCs, microbial infection induces a wave of production of a new DC subtype. The functional implications of this shift in the DC network remain to be determined.