Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells

作者：Wanjuan Yang, Jorge Soares, Patricia Greninger, Elena J. Edelman, Howard W. Lightfoot, Simon Andrew Forbes, Nidhi Bindal, Dave Beare, James Allen Smith, Ian Richard Thompson, Sridhar Ramaswamy, P. Andrew Futreal, Daniel A. Haber, Michael R. Stratton, Cyril H. Benes, Ultan McDermott, Mathew J. Garnett · 发表于：Nucleic Acids Research · 年份：2012 · DOI：10.1093/nar/gks1111 · 被引用次数：4423 · 研究领域：Cancer Genomics and Diagnostics、Lung Cancer Treatments and Mutations、Computational Drug Discovery Methods

Alterations in cancer genomes strongly influence clinical responses to treatment and in many instances are potent biomarkers for response to drugs. The Genomics of Drug Sensitivity in Cancer (GDSC) database (www.cancerRxgene.org) is the largest public resource for information on drug sensitivity in cancer cells and molecular markers of drug response. Data are freely available without restriction. GDSC currently contains drug sensitivity data for almost 75 000 experiments, describing response to 138 anticancer drugs across almost 700 cancer cell lines. To identify molecular markers of drug response, cell line drug sensitivity data are integrated with large genomic datasets obtained from the Catalogue of Somatic Mutations in Cancer database, including information on somatic mutations in cancer genes, gene amplification and deletion, tissue type and transcriptional data. Analysis of GDSC data is through a web portal focused on identifying molecular biomarkers of drug sensitivity based on queries of specific anticancer drugs or cancer genes. Graphical representations of the data are used throughout with links to related resources and all datasets are fully downloadable. GDSC provides a unique resource incorporating large drug sensitivity and genomic datasets to facilitate the discovery of new therapeutic biomarkers for cancer therapies.