Differentiation between genetic mutations of breast cancer by breath volatolomics

作者：Orna Barash, Wei Zhang, Jeffrey Mark Halpern, Qingling Hua, Yue-Yin Pan, Haneen Kayal, Kayan Khoury, Hu Liu, Michael P.A. Davies, Hossam Haick · 发表于：Oncotarget · 年份：2015 · DOI：10.18632/oncotarget.6269 · 被引用次数：100 · 研究领域：Advanced Chemical Sensor Technologies、Biochemical Analysis and Sensing Techniques、Olfactory and Sensory Function Studies

// Orna Barash 1, * , Wei Zhang 2, * , Jeffrey M. Halpern 1, †, * , Qing-Ling Hua 2 , Yue-Yin Pan 2 , Haneen Kayal 1 , Kayan Khoury 1 , Hu Liu 2 , Michael P.A. Davies 3 , Hossam Haick 1 1 Department of Chemical Engineering and Russel Berrie Nanotechnology Institute, Technion-Israel Institute of Technology, Haifa, Israel 2 Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Anhui, China 3 Molecular & Clinical Cancer Medicine, University of Liverpool, Cancer Research Centre, Liverpool, United Kingdom † Present Address: Department of Chemical Engineering, University of New Hampshire, Durham, NH, USA * These authors have contributed equally to this work Correspondence to: Hossam Haick, e-mail: hhossam@technion.ac.il Michael Davies, e-mail: michael.davies@liv.ac.uk Hu Liu, e-mail: drliuhu@gmail.com Keywords: breast cancer, molecular, volatolomic, sensor, spectrometry Received: August 17, 2015      Accepted: October 10, 2015      Published: November 02, 2015 ABSTRACT Mapping molecular sub-types in breast cancer (BC) tumours is a rapidly evolving area due to growing interest in, for example, targeted therapy and screening high-risk populations for early diagnosis. We report a new concept for profiling BC molecular sub-types based on volatile organic compounds (VOCs). For this purpose, breath samples were collected from 276 female volunteers, including healthy, benign conditions, ductal...