Adequacy of Early Empiric Antibiotic Treatment and Survival in Severe Sepsis: Experience from the MONARCS Trial

作者：Rodger D. MacArthur, Mark JS Miller, Timothy Albertson, Edward A. Panacek, David H. Johnson, Leah S. Teoh, William Barchuk · 发表于：Clinical Infectious Diseases · 年份：2004 · DOI：10.1086/379825 · 被引用次数：274 · 研究领域：Bacterial Identification and Susceptibility Testing、Sepsis Diagnosis and Treatment、Antibiotic Use and Resistance

As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study enrolled 2634 patients, 91% of whom received adequate antibiotic therapy. The mortality rate among patients given adequate antibiotic treatment was 33%, versus 43% among patients given inadequate treatment (P<.001). We conclude that adequate antibiotic therapy results in a significant decrease in the crude mortality rate among patients suspected of sepsis.