Impact of overweight and underweight on assisted reproduction treatment

作者：Péter Fedorcsák, Per Olav Dale, Ritsa Storeng, Gudvor Ertzeid, Sverre Bjercke, Nan Birgitte Oldereid, Anne Katerine Omland, Thomas Åbyholm, Tom Gunnar Tanbo · 发表于：Human Reproduction · 年份：2004 · DOI：10.1093/humrep/deh485 · 被引用次数：528 · 研究领域：Ovarian function and disorders、Gestational Diabetes Research and Management、Reproductive Health and Technologies

BACKGROUND: Underweight and overweight may affect reproduction and interfere with treatment of infertility. The purpose of this report is to describe the independent effect of body weight on treatment with IVF and ICSI. METHODS: Records of 5019 IVF or ICSI treatments in 2660 couples were reviewed. The influence of body mass index (BMI) on treatment outcome was examined, after accounting for differences in age and infertility diagnosis. RESULTS: The cumulative live birth rate within three treatment cycles was 41.4% [95% confidence interval (CI) 32.1-50.7] in obese women with BMI > or =30 kg/m2 and 50.3 (95% CI 47.0-53.7) in normal weight women with BMI 18.5-24.9 kg/m2. Obesity was associated with an increased risk of early pregnancy loss occurring before 6 weeks gestation. Positive correlation between BMI and gonadotrophin requirement during stimulation and negative correlation between BMI and number of collected oocytes were observed. Underweight (BMI <18.5 kg/m2) was not related to an impaired outcome of IVF or ICSI. CONCLUSIONS: Obesity is associated with lower chances for live birth after IVF and ICSI and with an impaired response to ovarian stimulation.