Characterization of a novel orthoreovirus isolated from fruit bat, China

作者：Tingsong Hu, Wei Qiu, Biao He, Yan Zhang, Jing Yu, Liang Xiu, Wendong Zhang, Gang Chen, Yingguo Zhang, Yiyin Wang, Ying Zheng, Ziliang Feng, Yonghe Hu, Weiguo Zhou, Changchun Tu, Quanshui Fan, Fuqiang Zhang · 发表于：BMC Microbiology · 年份：2014 · DOI：10.1186/s12866-014-0293-4 · 被引用次数：42 · 研究领域：Viral gastroenteritis research and epidemiology、Virus-based gene therapy research、Respiratory viral infections research

BACKGROUND: In recent years novel human respiratory disease agents have been described for Southeast Asia and Australia. The causative pathogens were classified as pteropine orthoreoviruses with a strong phylogenetic relationship to orthoreoviruses of bat origin. RESULTS: In this report, we isolated a novel Melaka-like reovirus (named "Cangyuan virus") from intestinal content samples of one fruit bat residing in China's Yunnan province. Phylogenetic analysis of the whole Cangyuan virus genome sequences of segments L, M and S demonstrated the genetic diversity of the Cangyuan virus. In contrast to the L and M segments, the phylogenetic trees for the S segments of Cangyuan virus demonstrated a greater degree of heterogeneity. CONCLUSIONS: Phylogenetic analysis indicated that the Cangyuan virus was a novel orthoreovirus and substantially different from currently known members of Pteropine orthoreovirus (PRV) species group.