Three New Germacrane-Type Sesquiterpenes with NGF-Potentiating Activity from Valeriana officinalis var. latiofolia

作者：Hengwen Chen, Lixia Chen, Bin Li, Hai-Long Yin, Ying Tian, Qiong Wang, Yanhua Xiao, Jun-Xing Dong · 发表于：Molecules · 年份：2013 · DOI：10.3390/molecules181114138 · 被引用次数：19 · 研究领域：Medicinal Plant Extracts Effects、Migraine and Headache Studies、Phytochemistry and Biological Activities

Three new germacrane-type sesquiterpenoids, volvalerenal F (1), volvalerenal G (2) and volvalerenic acid D (3), along with five known compounds 4-8, were isolated from the CHCl₃ soluble partition of the ethanol extract of Valeriana officinalis var. latiofolia. The structures of the new compounds were determined on the basis of spectroscopic evidence, including their 1D- and 2D-NMR spectra, as well as mass spectrometry. The eight germacrane-type sesquiterpenoids showed nerve growth factor (NGF) potentiating activity, which mediates the neurite outgrowth in PC 12D cells. This study intends to reveal the chemical basis of the use of V. officinalis var. latiofolia as a dietary supplement.