Case-Control Study of Enteropathogens Associated with Childhood Diarrhea in Dhaka, Bangladesh

作者：Manuel John Albert, Abu Syed Golam Faruque, Shah M. Faruque, R. Bradley Sack, Dilip Mahalanabis · 发表于：Journal of Clinical Microbiology · 年份：1999 · DOI：10.1128/jcm.37.11.3458-3464.1999 · 被引用次数：333 · 研究领域：Viral gastroenteritis research and epidemiology、Escherichia coli research studies、Vibrio bacteria research studies

The International Centre for Diarrhoeal Disease Research, Bangladesh, is a major center for research into diarrheal diseases. The center treats more than 100,000 patients a year. To obtain useful information representative of all patients, a surveillance system in which a 4% systematic sample of all patients is studied in detail, including etiological agents of diarrhea, was installed in October 1979. The first paper on etiology for the surveillance patients was published in 1982, which identified a potential enteric pathogen in 66% of patients. In subsequent years, several new agents of diarrhea have been identified. To assess the importance of a broader spectrum of diarrheal agents including the ones identified relatively recently, we studied 814 children with diarrhea. The children were up to 5 years of age and were part of the surveillance system. They were matched with an equal number of community controls without diarrhea. The study was conducted from February 1993 to June 1994. A potential enteric pathogen was isolated from 74.8% of diarrheal children and 43.9% of control children (P = 0.0001). Even though the first study was not a case-control study, it identified rotavirus, Campylobacter jejuni, enterotoxigenic Escherichia coli, Shigella spp. , and Vibrio cholerae O1 as major pathogens. The present study identified these pathogens as being significantly associated with diarrhea. In addition, the study also identified six additional agents, including enteropathogenic ...