Efficacy of Ethanol against Trichosporon asahii Biofilm in vitro

作者：Yong Liao, Hui Zhao, Xuelian Lu, Suteng Yang, Jian-Feng Zhou, Rong Yang · 发表于：Medical Mycology · 年份：2015 · DOI：10.1093/mmy/myv006 · 被引用次数：15 · 研究领域：Antifungal resistance and susceptibility、Bacterial biofilms and quorum sensing、Occupational exposure and asthma

Trichosporon asahii (T. asahii) can cause invasive infections, particularly catheter-related bloodstream infections (CR-BSIs). T. asahii biofilm, which is resistant to the most common clinical antifungal agents, may play an important role in these life-threatening infections. This study focused on the effects of ethanol on the different phases of T. asahii biofilm formation. At the concentrations clinically used, ethanol killed T. asahii planktonic cells (MIC90 = 15% and m-MIC90 = 15%) and biofilm (SMIC90 = 50%), and exposure to 25% ethanol for 12 h or to 50% ethanol for 8 h completely inhibited biofilm development and eradicated mature T. asahii biofilm. Thus, our results showed that ethanol effectively inhibited the main phases of T. asahii biofilm formation. This study reveals a new potential strategy to prevent and treat T. asahii biofilm-related CR-BSIs.