New Strategies for the Synthesis of Pyrimidine Derivatives

作者：Matthew Davenport Hill, Mohammad Movassaghi · 发表于：Chemistry - A European Journal · 年份：2008 · DOI：10.1002/chem.200800014 · 被引用次数：138 · 研究领域：Advanced Synthetic Organic Chemistry、Quinazolinone synthesis and applications、Chemical Synthesis and Analysis

Recent advances in pyrimidine synthesis are described. Modification of conventional strategies involving N-C-N fragment condensation with 1,3-dicarbonyl derivatives remains a common theme in current literature. Other methods, including N-C fragment condensation strategies, provide reactive intermediates capable of intramolecular cyclization and formation of pyrimidine derivatives. These recently developed methodologies offer a valuable addendum to azaheterocycle synthesis.