Immunometabolism: Cellular Metabolism Turns Immune Regulator

作者：Róisín M. Loftus, David K. Finlay · 发表于：Journal of Biological Chemistry · 年份：2015 · DOI：10.1074/jbc.r115.693903 · 被引用次数：459 · 研究领域：Immune Cell Function and Interaction、Immune cells in cancer、T-cell and B-cell Immunology

Immune cells are highly dynamic in terms of their growth, proliferation, and effector functions as they respond to immunological challenges. Different immune cells can adopt distinct metabolic configurations that allow the cell to balance its requirements for energy, molecular biosynthesis, and longevity. However, in addition to facilitating immune cell responses, it is now becoming clear that cellular metabolism has direct roles in regulating immune cell function. This review article describes the distinct metabolic signatures of key immune cells, explains how these metabolic setups facilitate immune function, and discusses the emerging evidence that intracellular metabolism has an integral role in controlling immune responses.