Brain Metabolism during Fasting*

作者：O E Owen, Alfred P. Morgan, H. G. Kemp, James M. Sullivan, M. Guillermo Herrera, George F. Cahill · 发表于：Journal of Clinical Investigation · 年份：1967 · DOI：10.1172/jci105650 · 被引用次数：1648 · 研究领域：Diet and metabolism studies、Metabolomics and Mass Spectrometry Studies、Eicosanoids and Hypertension Pharmacology

Catheterization of cerebral vessels in three obese patients undergoing 5-6 wk of starvation demonstrated that beta-hydroxybutyrate and acetoacetate replaced glucose as the predominant fuel for brain metabolism. A strikingly low respiratory quotient was also observed, suggesting a carboxylation mechanism as a means of disposing of some of the carbon of the consumed substrates.