Identification of a human T lymphocyte surface protein associated with the E-rosette receptor.

作者：Malek Kamoun, Paul J. Martin, John A. Hansen, Matthew A. Brown, Anthony W. Siadak, Robert C. Nowinski · 发表于：The Journal of Experimental Medicine · 年份：1981 · DOI：10.1084/jem.153.1.207 · 被引用次数：409 · 研究领域：Monoclonal and Polyclonal Antibodies Research、Cell Adhesion Molecules Research、Receptor Mechanisms and Signaling

We describe a new monoclonal murine antibody that reacts with a 50,000-mol wt polypeptide that appears to be present on all E-rosetting cells. We conclude that this antigen is either identical to or closely associated with the E receptor because of (a) the high degree of concordance between E-rosette formation and 9.6 antigen expression, (b) the inhibition of rosette formation by preincubation of cells with 9.6 antibody, and (c) the observed failure of cells lysostripped of 9.6 antigen to form E-rosettes. This last finding suggests cocapping of 9.6 antigen and the E receptor.