β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

作者：De Yang, Oleg Chertov, С. Н. Быковская, Q. Chen, Mary Jo Buffo, Jeffrey Shogan, Michael J. M. Anderson, Jens‐Michael Schröder, Ji Ming Wang, O. M. Zack Howard, Joost J. Oppenheim · 发表于：Science · 年份：1999 · DOI：10.1126/science.286.5439.525 · 被引用次数：1817 · 研究领域：Antimicrobial Peptides and Activities、Polydiacetylene-based materials and applications、Immunotherapy and Immune Responses

Defensins contribute to host defense by disrupting the cytoplasmic membrane of microorganisms. This report shows that human beta-defensins are also chemotactic for immature dendritic cells and memory T cells. Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells. The beta-defensin-induced chemotaxis was sensitive to pertussis toxin and inhibited by antibodies to CCR6. The binding of iodinated LARC, the chemokine ligand for CCR6, to CCR6-transfected cells was competitively displaced by beta-defensin. Thus, beta-defensins may promote adaptive immune responses by recruiting dendritic and T cells to the site of microbial invasion through interaction with CCR6.